Issue 38, 2014
From the journal:

RSC Advances

Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect†

Su-Yun Bai,‡ac   Xi Dai,‡b   Bao-Xiang Zhao*b  and  Jun-Ying Miao*a  

* Corresponding authors

a Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P.R. China
E-mail: miaojy@sdu.edu.cn
Fax: +86 531 88565610
Tel: +86 531 88364929

b Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China
E-mail: bxzhao@sdu.edu.cn

c School of Basic Medical Sciences, Taishan Medical University, Taian 271000, P.R. China

Abstract

A series of novel fluorescent pyrazoline coumarin derivatives were synthesized. From them, we screened a compound possessing strong growth inhibitory effects on lung cancer cells. By taking advantage of fluorescence combined with LC-MS/MS and chemoinformatics technique, we successfully identified HSP90 as the target of the compound.

Graphical abstract: Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect

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Article information

DOI
https://doi.org/10.1039/C4RA01800A
Article type
Communication
Submitted
01 Mar 2014
Accepted
02 Apr 2014
First published
07 Apr 2014

RSC Adv., 2014,4, 19887-19890

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Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect

S. Bai, X. Dai, B. Zhao and J. Miao, RSC Adv., 2014, 4, 19887 DOI: 10.1039/C4RA01800A

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