Issue 22, 2014
From the journal:

RSC Advances

Copper(ii)-catalyzed cascade approach for the synthesis of pyrrolo[2,1-f][1,2,4]triazine-fused isoquinolines†

Jianyang Chen,a   Bo Liu,*b   Yanhong Chen,a   Qian Hea  and  Chunhao Yang*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai 201203, P.R. China
E-mail: chyang@simm.ac.cn
Fax: +86-21-50806770

b Guangdong Provincial Academy of Chinese Medical Sciences, (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), 5th Floor, Science Building, 55 Neihuanxi Road, Guangzhou Higher Education Mega Center, Guangzhou, P.R. China
E-mail: doctliu@263.net

Abstract

We report herein a one-pot copper(II)-catalyzed coupling-cyclization leading to small molecules based on a novel structural motif, i.e. the pyrrolo[2,1-f][1,2,4]triazine moiety fused with an isoquinoline ring. The reaction is easy to perform in good to excellent yields with high atom economy and exhibits a broad substrate scope.

Graphical abstract: Copper(ii)-catalyzed cascade approach for the synthesis of pyrrolo[2,1-f][1,2,4]triazine-fused isoquinolines

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Article information

DOI
https://doi.org/10.1039/C3RA47324D
Article type
Paper
Submitted
05 Dec 2013
Accepted
04 Feb 2014
First published
10 Feb 2014

RSC Adv., 2014,4, 11168-11175

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Copper(II)-catalyzed cascade approach for the synthesis of pyrrolo[2,1-f][1,2,4]triazine-fused isoquinolines

J. Chen, B. Liu, Y. Chen, Q. He and C. Yang, RSC Adv., 2014, 4, 11168 DOI: 10.1039/C3RA47324D

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