Facile fabrication of reduction-responsive nanocarriers for controlled drug release

Rui Sun; Qiaojie Luo; Chen Gao; Ying Wang; Lilong Gao; Hong Du; Ying Huang; Xiaodong Li; Zhiquan Shen; Weipu Zhu

doi:10.1039/C4PY00577E

Facile fabrication of reduction-responsive nanocarriers for controlled drug release†

Rui Sun,‡^a Qiaojie Luo,‡^b Chen Gao,^a Ying Wang,^a Lilong Gao,^a Hong Du,^a Ying Huang,^b Xiaodong Li,^b Zhiquan Shen^a and Weipu Zhu*^a

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* Corresponding authors

^a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
E-mail: zhuwp@zju.edu.cn

^b Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, P. R. China

Abstract

An amphiphilic multiblock poly(ether–ester) containing multiple thiols was facilely synthesized by “one-pot” polycondensation of dihydroxyl poly(ethylene glycol), 1,4-butanediol and mercaptosuccinic acid, which could be used to fabricate reduction-responsive core-crosslinked micelles for controlled drug release.

Polymer Chemistry

Facile fabrication of reduction-responsive nanocarriers for controlled drug release†

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Facile fabrication of reduction-responsive nanocarriers for controlled drug release

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