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Thermally induced cascade sigmatropic rearrangement of a butynyloxycoumarin derivative has led to a quick access to the coumarin–pterocarpan hybrid molecule. Biophysical studies together with molecular modeling show that this nature-inspired hybrid molecule is capable of binding to the minor groove of DNA as a non-conventional entity.

Graphical abstract: The coumarin–pterocarpan conjugate – a natural product inspired hybrid molecular probe for DNA recognition

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