Issue 32, 2014

Catalytic functionalization of tertiary alcohols to fully substituted carbon centres

Abstract

The catalytic nucleophilic substitution of tertiary alcohols using carbon or heteroatom based nucleophiles is a versatile methodology for the efficient, diverse and atom economical construction of fully substituted carbon centres, including both quaternary carbons and heteroatom substituted tetrasubstituted carbons, which only produces water as the by-product. This review summarizes the recent progress in this field, including the catalytic asymmetric studies and their application in the natural product synthesis, briefly discusses the reaction mechanism and challenges, and outlines synthetic opportunities that are still open.

Graphical abstract: Catalytic functionalization of tertiary alcohols to fully substituted carbon centres

Article information

Article type
Review Article
Submitted
04 Apr 2014
Accepted
21 May 2014
First published
21 May 2014

Org. Biomol. Chem., 2014,12, 6033-6048

Catalytic functionalization of tertiary alcohols to fully substituted carbon centres

L. Chen, X. Yin, C. Wang and J. Zhou, Org. Biomol. Chem., 2014, 12, 6033 DOI: 10.1039/C4OB00718B

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