Xiaoe Wang, Daqian Xu, Chengxia Miao, Qiaohong Zhang and Wei Sun
Org. Biomol. Chem., 2014,12, 3108-3113
DOI:
10.1039/C4OB00386A,
Paper
A facile and transition-metal-free method was developed through merging the ring opening of benzoxazoles with secondary amines and N-bromosuccinimide (NBS) mediated oxidative cyclization toward the synthesis of 2-aminobenzoxazoles. NBS was selected as a powerful oxidant in the oxidative cyclization of ring-opening amidines to provide the desirable 2-aminobenzoxazoles in excellent yields (up to 94%).
