Synthetic strategies toward hetidine and hetisine-type diterpenoid alkaloids

Abstract

Within the diterpenoid alkaloid family of natural products, the hetidine and hetisine structural types have been the targets of a number of synthetic studies. Various strategies have been pursued to access the azacyclic moiety of these natural products as well as the characteristic [2.2.2] bicyclic structural motif. This perspective article examines the different disconnections and approaches that have been applied to the synthesis of these natural products to date.