Issue 12, 2014

Synthesis of substituted oxazoles from enamides

Abstract

Annulation of enamides into 2,5- and 2,4,5-substituted oxazoles by NBS/Me2S in the presence of mild base has been achieved. The reaction conditions are simple and tolerant to a wide variety of substituents including both electron-donating and withdrawing groups to produce oxazoles in one-pot without further purification of the intermediate.

Graphical abstract: Synthesis of substituted oxazoles from enamides

Supplementary files

Article information

Article type
Paper
Submitted
02 Jul 2014
Accepted
01 Aug 2014
First published
01 Aug 2014

New J. Chem., 2014,38, 5727-5735

Author version available

Synthesis of substituted oxazoles from enamides

N. Panda and R. Mothkuri, New J. Chem., 2014, 38, 5727 DOI: 10.1039/C4NJ01101E

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