Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity

Sumit O. Bajaj; Pei Shi; Penny J. Beuning; George A. O'Doherty

doi:10.1039/C4MD00095A

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Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity†

Sumit O. Bajaj,‡^a Pei Shi,‡^a Penny J. Beuning*^a and George A. O'Doherty*^a

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* Corresponding authors

^a Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA
E-mail: G.ODoherty@neu.edu

Abstract

Ten members of the mezzettiaside family of natural products were synthesized and evaluated for anticancer and antibacterial activity. Complete anticancer (H460) and antibacterial (B. subtilis) activities for the ten natural products and four new analogues were found. Comparison to the cleistrioside and cleistetroside classes of natural products were made.

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Article information

DOI: https://doi.org/10.1039/C4MD00095A
Article type: Concise Article
Submitted: 04 Mar 2014
Accepted: 20 Mar 2014
First published: 21 Mar 2014

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Med. Chem. Commun., 2014,5, 1138-1142

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Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity

S. O. Bajaj, P. Shi, P. J. Beuning and G. A. O'Doherty, Med. Chem. Commun., 2014, 5, 1138 DOI: 10.1039/C4MD00095A

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Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity†

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Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity

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