Issue 8, 2015
From the journal:

Chemical Communications

N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes†

Y. Wanga  and  S. R. McAlpine*a  

* Corresponding authors

a Department of chemistry, Gate 2 High street, Dalton 219, University of New South Wales, Sydney, NSW, Australia
E-mail: s.mcalpine@unsw.edu.au

Abstract

Classic oncogenic heat shock protein 90 (Hsp90) inhibitors target the N-terminus of the protein, triggering a survival mechanism in cancer cells referred to as the heat shock response (HSR). Inhibiting Hsp90 by modulating the C-terminus does not trigger a HSR, making it a highly attractive chemotherapeutic approach.

Graphical abstract: N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes

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Article information

DOI
https://doi.org/10.1039/C4CC07284G
Article type
Communication
Submitted
15 Sep 2014
Accepted
15 Oct 2014
First published
16 Oct 2014

Chem. Commun., 2015,51, 1410-1413

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N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes

Y. Wang and S. R. McAlpine, Chem. Commun., 2015, 51, 1410 DOI: 10.1039/C4CC07284G

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