We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.
R. D. Teo, H. B. Gray, P. Lim, J. Termini, E. Domeshek and Z. Gross, Chem. Commun., 2014, 50, 13789 DOI: 10.1039/C4CC06577H
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