19F NMR indicator displacement assay using a synthetic receptor with appended paramagnetic relaxation agent

Adam J. Plaunt; Kasey J. Clear; Bradley D. Smith

doi:10.1039/C4CC04159C

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¹⁹F NMR indicator displacement assay using a synthetic receptor with appended paramagnetic relaxation agent†

Adam J. Plaunt,^a Kasey J. Clear^a and Bradley D. Smith*^a

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* Corresponding authors

^a Department of Chemistry and Biochemistry, University of Notre Dame, 236 Nieuwland Science Hall, Notre Dame, IN, USA
E-mail: smith.115@nd.edu
Tel: +1-574-631-8632

Abstract

An admixture of zinc(II)-bis(dipicolylamine) receptor with covalently attached paramagnetic relaxation agent and fluorine-labeled phosphate indicator enables ¹⁹F NMR detection of phosphorylated analytes with amplified switched-on signal intensity.

This article is part of the themed collection: In celebration of Seiji Shinkai's 70th Birthday

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Article information

DOI: https://doi.org/10.1039/C4CC04159C
Article type: Communication
Submitted: 30 May 2014
Accepted: 17 Jul 2014
First published: 21 Jul 2014

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Chem. Commun., 2014,50, 10499-10501

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¹⁹F NMR indicator displacement assay using a synthetic receptor with appended paramagnetic relaxation agent

A. J. Plaunt, K. J. Clear and B. D. Smith, Chem. Commun., 2014, 50, 10499 DOI: 10.1039/C4CC04159C

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Chemical Communications