Issue 64, 2014

Negatively-charged helices in the gas phase

Abstract

A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.

Graphical abstract: Negatively-charged helices in the gas phase

Supplementary files

Article information

Article type
Communication
Submitted
01 May 2014
Accepted
28 May 2014
First published
29 May 2014

Chem. Commun., 2014,50, 8849-8851

Negatively-charged helices in the gas phase

A. R. Johnson, J. M. Dilger, M. S. Glover, D. E. Clemmer and E. E. Carlson, Chem. Commun., 2014, 50, 8849 DOI: 10.1039/C4CC03257H

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