Ni(II)–salt catalyzed activation of primary amine-sp3Cα–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles

Srikanta Samanta; Dipanwita Roy; Saikat Khamarui; Dilip K. Maiti

doi:10.1039/C3CC48437H

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Ni(ii)–salt catalyzed activation of primary amine-sp³C_α–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles†

Srikanta Samanta,^a Dipanwita Roy,^a Saikat Khamarui^a and Dilip K. Maiti*^a

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^a Department of Chemistry, University of Calcutta, University College of Science, 92, A. P. C. Road, Kolkata-700009, India
E-mail: dkmchem@caluniv.ac.in
Fax: +91-33-2351-9755
Tel: +91-33-2350-9937

Abstract

NiCl₂·6H₂O and Ni(OAc)₂·4H₂O were found as efficient catalysts for C–H activation of benzyl and aliphatic amines for an unprecedented multi C–N bond forming cyclization with 1,2-diketones under refluxing toluene to furnish highly substituted and polycyclic imidazoles.

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Article information

DOI: https://doi.org/10.1039/C3CC48437H
Article type: Communication
Submitted: 04 Nov 2013
Accepted: 03 Dec 2013
First published: 03 Dec 2013

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Chem. Commun., 2014,50, 2477-2480

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Ni(II)–salt catalyzed activation of primary amine-sp³C_α–H and cyclization with 1,2-diketone to tetrasubstituted imidazoles

S. Samanta, D. Roy, S. Khamarui and D. K. Maiti, Chem. Commun., 2014, 50, 2477 DOI: 10.1039/C3CC48437H

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