Issue 34, 2013

Lithium hydroxide mediated synthesis of 3,4-disubstituted pyrroles

Abstract

LiOH·H2O in ethanol was found to be an effective reagent for the synthesis of 3,4-disubstituted pyrrole derivatives by the van Leusen method. In situ formation of chalcones from aromatic aldehydes and enolisable ketones, and their subsequent reaction with tosylmethyl isocyanide resulted in the formation and precipitation of pyrrole derivatives from the reaction medium, in good yields. The solvation effect of the polar medium facilitates the reaction.

Graphical abstract: Lithium hydroxide mediated synthesis of 3,4-disubstituted pyrroles

Article information

Article type
Paper
Submitted
25 May 2013
Accepted
12 Jun 2013
First published
17 Jun 2013

RSC Adv., 2013,3, 14521-14527

Lithium hydroxide mediated synthesis of 3,4-disubstituted pyrroles

R. Sharma, K. Kumar, M. Chouhan, V. Grover and V. A. Nair, RSC Adv., 2013, 3, 14521 DOI: 10.1039/C3RA42569J

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