Issue 17, 2013
From the journal:

RSC Advances

Pot, atom and step economic synthesis: a diversity-oriented approach to construct 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones†

Haoyue Xiang,a   Yanhong Chen,a   Qian He,a   Yuyuan Xiea  and  Chunhao Yang*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, P. R. China
E-mail: chyang@mail.shcnc.ac.cn, chyang@simm.ac.cn
Fax: 86-21-50806770
Tel: 86-21-50806770

Abstract

A diversity-oriented approach to construct 2-heteroaryl-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one derivatives via copper-promoted two-step one pot reactions from chromenone derivatives has been developed. Pot, atom and step economy (PASE) were combined in these sequential reactions, and at least six bonds were formed in one pot. A number of drug-like small molecules were prepared quickly and efficiently.

Graphical abstract: Pot, atom and step economic synthesis: a diversity-oriented approach to construct 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones

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Article information

DOI
https://doi.org/10.1039/C3RA22909B
Article type
Communication
Submitted
15 Nov 2012
Accepted
13 Feb 2013
First published
28 Feb 2013

RSC Adv., 2013,3, 5807-5810

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Pot, atom and step economic synthesis: a diversity-oriented approach to construct 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones

H. Xiang, Y. Chen, Q. He, Y. Xie and C. Yang, RSC Adv., 2013, 3, 5807 DOI: 10.1039/C3RA22909B

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