Magnetically recyclable γ-Fe2O3–HAP nanoparticles for the cycloaddition reaction of alkynes, halides and azides in aqueous media

Abstract

A simple and novel γ-Fe₂O₃ supported on hydroxyapatite (HAP) heterogeneous catalytic system is described that is useful in the synthesis of disubstituted 1,2,3-triazoles from terminal alkynes and in situ generated organic azide in aqueous media; this green methodology emerges as this new catalyst for the one-pot synthesis of 1,2,3-triazoles can be used in water without the addition of any reagent/base. The catalyst can be successfully recycled five times without significant loss of activity. It is important to note that 100% regioselectivity was observed for the cycloaddition reaction.