Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B†
Abstract
A screen of a library of diverse small-molecules against a subset of phosphatases identified 7b and 7c, which potently inhibit TC-PTP, PTPσ and PTP1B with no inhibition of PTP-LAR, PRL2 A/S, MKPX or papain. In CHO-IR cells these