Issue 2, 2013

Inhibition of Ras–effector interactions by cyclic peptides

Abstract

A combinatorial library of 6 × 106 cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins.

Graphical abstract: Inhibition of Ras–effector interactions by cyclic peptides

Supplementary files

Article information

Article type
Concise Article
Submitted
31 Oct 2012
Accepted
24 Nov 2012
First published
27 Nov 2012

Med. Chem. Commun., 2013,4, 378-382

Inhibition of Ras–effector interactions by cyclic peptides

X. Wu, P. Upadhyaya, M. A. Villalona-Calero, R. Briesewitz and D. Pei, Med. Chem. Commun., 2013, 4, 378 DOI: 10.1039/C2MD20329D

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