Issue 10, 2013
From the journal:

Lab on a Chip

Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood†

Zheng Zhang,*a   Jeffrey Borenstein,b   Linda Guiney,a   Raanan Miller,b   Sivaprasad Sukavaneshvarc  and  Christopher Loosea  

* Corresponding authors

a Semprus BioSciences, MA, USA
E-mail: Jonathan.Zhang@semprusbio.com

b Draper Laboratory, MA, USA

c Thrombodyne Inc., UT, USA

Abstract

Assembled polydimethylsiloxane microfluidic devices were modified with a sulfobetaine polymer through continuous “tip-to-tip” modification, significantly reducing blood clotting and extending device patency under blood flow. This technology can be designed to enable the development of devices that can continuously work in whole blood, especially in an extracorporeal or in vivo environment.

Graphical abstract: Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3LC50302J
Article type
Paper
Submitted
05 Mar 2013
Accepted
12 Mar 2013
First published
12 Mar 2013

Lab Chip, 2013,13, 1963-1968

Permissions

Request permissions

Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood

Z. Zhang, J. Borenstein, L. Guiney, R. Miller, S. Sukavaneshvar and C. Loose, Lab Chip, 2013, 13, 1963 DOI: 10.1039/C3LC50302J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements