Issue 39, 2013
From the journal:

Chemical Communications

Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers†‡

Hien T. T. Duong,a   Zulkamal M. Kamarudin,a   Rafael B. Erlich,ab   Yang Li,a   Mathew W. Jones,a   Maria Kavallaris,ab   Cyrille Boyer*a  and  Thomas P. Davis*a  

* Corresponding authors

a Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, The University of New South Wales, Sydney, Australia

b Children's Cancer Institute Australia, Lowy Cancer Research Centre, The University of New South Wales, Sydney, Australia
E-mail: t.davis@unsw.edu.au, cboyer@unsw.edu.au

Abstract

The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.

Graphical abstract: Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

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Article information

DOI
https://doi.org/10.1039/C2CC37181B
Article type
Communication
Submitted
02 Oct 2012
Accepted
25 Oct 2012
First published
16 Nov 2012

Chem. Commun., 2013,49, 4190-4192

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Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

H. T. T. Duong, Z. M. Kamarudin, R. B. Erlich, Y. Li, M. W. Jones, M. Kavallaris, C. Boyer and T. P. Davis, Chem. Commun., 2013, 49, 4190 DOI: 10.1039/C2CC37181B

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