Synthon polymorphs of sulfacetamide–acetamide cocrystal based on N–H⋯OS and N–H⋯OC hydrogen bonding

Abstract

A rare case of polymorphism in SO₂–NH–CO containing molecules is reported in the 1 : 1 cocrystal of sulfacetamide (SACT) and acetamide (ACT). The R⁴₄(16) ring motif in polymorph 1 is assembled via N–H⋯OS and N–H⋯OC H-bonds whereas a similar hydrogen-bonded ring motif made of N–H⋯OC H-bonds only is present in form 2.