Jicong Cao, Manish Arha, Chaitanya Sudrik, Lukasz J. Bugaj, David V. Schaffer and Ravi S. Kane
Chem. Commun., 2013,49, 8338-8340
DOI:
10.1039/C3CC44866E,
Communication
A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.
