A “signal on” approach for ultrasensitive detection of bleomycin was developed by bleomycin–Fe(II) induced hairpin DNA scission to release its loop, which was subsequently recycled with the aid of exonuclease III and a probe to amplify the detectable fluorescent signal.
F. Gao, J. Lei and H. Ju, Chem. Commun., 2013, 49, 7561 DOI: 10.1039/C3CC44275F
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