Issue 82, 2013
From the journal:

Chemical Communications

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform†

Anita Gianella,a   Aneta J. Mieszawska,a   Freek J. M. Hoeben,b   Henk M. Janssen,b   Peter A. Jarzyna,a   David P. Cormode,a   Kevin D. Costa,c   Satish Rao,c   Omid C. Farokhzad,d   Robert Langer,e   Zahi A. Fayada  and  Willem J. M. Mulder*af  

* Corresponding authors

a Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
E-mail: willem.mulder@mssm.edu

b SyMO-Chem B.V., Eindhoven, The Netherlands

c Cardiovascular Cell and Tissue Engineering Laboratory, Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA

d Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA

e Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

f Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands

Abstract

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.

Graphical abstract: Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

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Article information

DOI
https://doi.org/10.1039/C3CC43618G
Article type
Communication
Submitted
14 May 2013
Accepted
11 Jul 2013
First published
12 Jul 2013

Chem. Commun., 2013,49, 9392-9394

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Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

A. Gianella, A. J. Mieszawska, F. J. M. Hoeben, H. M. Janssen, P. A. Jarzyna, D. P. Cormode, K. D. Costa, S. Rao, O. C. Farokhzad, R. Langer, Z. A. Fayad and W. J. M. Mulder, Chem. Commun., 2013, 49, 9392 DOI: 10.1039/C3CC43618G

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