Issue 26, 2013
From the journal:

Chemical Communications

pH-sensitive DNA cleaving agents: in situactivation by ring contraction of benzo-fused cyclobutanols†

Yuuki Nagamoto,a   Akira Hattori,a   Hideaki Kakeya,a   Yoshiji Takemoto*a  and  Kiyosei Takasu*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 505-8501, Japan
E-mail: kay-t@pharm.kyoto-u.ac.jp
Fax: +81-75-753-4604
Tel: +81-75-753-4553

Abstract

Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.

Graphical abstract: pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols

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Article information

DOI
https://doi.org/10.1039/C3CC39246E
Article type
Communication
Submitted
28 Dec 2012
Accepted
13 Feb 2013
First published
14 Feb 2013

Chem. Commun., 2013,49, 2622-2624

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pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols

Y. Nagamoto, A. Hattori, H. Kakeya, Y. Takemoto and K. Takasu, Chem. Commun., 2013, 49, 2622 DOI: 10.1039/C3CC39246E

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