Issue 8, 2012
From the journal:

Polymer Chemistry

Methoxy poly(ethylene glycol) conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin†

Liming Zhang,ab   Zhuoxuan Lu,‡*ab   Xiaolong Li,ab   Yan Deng,a   Fengqin Zhang,a   Chao Mab  and  Nongyue He‡*ab  

* Corresponding authors

a Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412008, P. R. China
E-mail: luzhuoxuan1981@163.com

b State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P. R. China
E-mail: nyhe1958@163.com

Abstract

A novel nontoxic denatured bovine serum albumin (dBSA)-based platform for effectively delivering drugs was prepared. It was demonstrated that the as-prepared dBSA micelles could effectively load and deliver a water insoluble anti-cancer drug in vitro assay. The results also indicated that the denaturization of the BSA did not enhance the cytotoxicity practically, but significantly enhanced its cellular uptake.

Graphical abstract: Methoxy poly(ethylene glycol) conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2PY20201H
Article type
Communication
Submitted
07 Apr 2012
Accepted
14 May 2012
First published
16 May 2012

Polym. Chem., 2012,3, 1958-1961

Permissions

Request permissions

Methoxy poly(ethylene glycol) conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin

L. Zhang, Z. Lu, X. Li, Y. Deng, F. Zhang, C. Ma and N. He, Polym. Chem., 2012, 3, 1958 DOI: 10.1039/C2PY20201H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements