Synthetic methods Part (i) Free-radical reactions

Abstract

Two topics dominate this year's review; the use of metals in radical transformations and photoredox catalysis for the generation of alkyl radicals. In the former category, the use of potassium tert-butoxide in conjunction with a diamine ligand as a means of forming aryl radicals has the potential for the greatest impact. The use of photoredox catalysis as a mild method of initiating radical reactions appears to have opened a new vista in free-radical chemistry. One of the more exciting advances in this area is the use of a simple organic dye instead of the more common ruthenium complexes.