Issue 30, 2012
From the journal:

Organic & Biomolecular Chemistry

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration†‡

Philippa B. Cranwell,a   Matthew O'Brien,a   Duncan L. Browne,a   Peter Koos,a   Anastasios Polyzos,a   Miguel Peña-Lópeza  and  Steven V. Ley*a  

* Corresponding authors

a Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk

Abstract

Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal–Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.

Graphical abstract: Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

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Article information

DOI
https://doi.org/10.1039/C2OB25407G
Article type
Communication
Submitted
24 Feb 2012
Accepted
21 Mar 2012
First published
21 Mar 2012

Org. Biomol. Chem., 2012,10, 5774-5779

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Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

P. B. Cranwell, M. O'Brien, D. L. Browne, P. Koos, A. Polyzos, M. Peña-López and S. V. Ley, Org. Biomol. Chem., 2012, 10, 5774 DOI: 10.1039/C2OB25407G

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