Issue 11, 2012

Lab-in-a-tube: ultracompact components for on-chip capture and detection of individual micro-/nanoorganisms

Abstract

A review of present and future on-chip rolled-up devices, which can be used to develop lab-in-a-tube total analysis systems, is presented. Lab-in-a-tube is the integration of numerous rolled-up components into a single device constituting a microsystem of hundreds/thousands of independent units on a chip, each individually capable of sorting, detecting and analyzing singular organisms. Such a system allows for a scale-down of biosensing systems, while at the same time increasing the data collection through a large, smart array of individual biosensors. A close look at these ultracompact components which have been developed over the past decade is given. Methods for the capture of biomaterial are laid out and progress of cell culturing in three-dimensional scaffolding is detailed. Rolled-up optical sensors based on photoluminescence, optomechanics, optofluidics and metamaterials are presented. Magnetic sensors are introduced as well as electrical components including heating, energy storage and resistor devices.

Graphical abstract: Lab-in-a-tube: ultracompact components for on-chip capture and detection of individual micro-/nanoorganisms

Supplementary files

Article information

Article type
Tutorial Review
Submitted
29 Nov 2011
Accepted
01 Mar 2012
First published
02 Mar 2012

Lab Chip, 2012,12, 1917-1931

Lab-in-a-tube: ultracompact components for on-chip capture and detection of individual micro-/nanoorganisms

E. J. Smith, W. Xi, D. Makarov, I. Mönch, S. Harazim, V. A. Bolaños Quiñones, C. K. Schmidt, Y. Mei, S. Sanchez and O. G. Schmidt, Lab Chip, 2012, 12, 1917 DOI: 10.1039/C2LC21175K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements