Issue 21, 2012
From the journal:

Chemical Society Reviews

Cationic polymers and their therapeutic potential

Sangram Keshari Samal,*a   Mamoni Dash,a   Sandra Van Vlierberghe,a   David L. Kaplan,b   Emo Chiellini,c   Clemens van Blitterswijk,d   Lorenzo Moronid  and  Peter Dubruel*a  

* Corresponding authors

a Polymer Chemistry & Biomaterials Research Group, Ghent University, Krijgslaan 281, S4-Bis, B-9000 Ghent, Belgium
E-mail: SangramKeshari.Samal@UGent.be, sksamalrec@gmail.com, Peter.Dubruel@ugent.be
Fax: +32-9-2644972
Tel: +32-9-2644466

b Department of Biomedical Engineering, 4 Colby Street, Tufts University, Medford, MA 02155, USA

c Laboratory of Bioactive Polymeric Materials for Biomedical & Environmental Application-UdR-INSTM @ Department of Chemistry and Industrial Chemistry, University of Pisa, via Vecchia Livornese, 1291, S. Piero a Grado, PI, Italy

d Institute for Biomedical Technology and Technical Medicine, Tissue Regeneration Department, University of Twente, Zuidhorst, ZH147, Drienerlolaan 5, PO Box 217, 7500 AE Enschede, The Netherlands

Abstract

The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.

Graphical abstract: Cationic polymers and their therapeutic potential

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Article information

DOI
https://doi.org/10.1039/C2CS35094G
Article type
Critical Review
Submitted
22 Mar 2012
First published
10 Aug 2012

Chem. Soc. Rev., 2012,41, 7147-7194

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Cationic polymers and their therapeutic potential

S. K. Samal, M. Dash, S. Van Vlierberghe, D. L. Kaplan, E. Chiellini, C. van Blitterswijk, L. Moroni and P. Dubruel, Chem. Soc. Rev., 2012, 41, 7147 DOI: 10.1039/C2CS35094G

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