Issue 93, 2012
From the journal:

Chemical Communications

Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel†‡

Na An,a   Henry S. White*a  and  Cynthia J. Burrows*a  

* Corresponding authors

a Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, USA
E-mail: burrows@chem.utah.edu, white@chem.utah.edu
Fax: +1 801 585 0024
Tel: +1 801 585 7290

Abstract

Electrical current signatures of DNA adducts were investigated during immobilization of strands inside the membrane-bound α-hemolysin ion channel. The current blockages produced by these adducts were found to depend on both size and shape, providing insights into the DNA–protein interactions and the size limitation of bulky adducts to be translocated.

Graphical abstract: Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel

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Article information

DOI
https://doi.org/10.1039/C2CC36366F
Article type
Communication
Submitted
31 Aug 2012
Accepted
08 Oct 2012
First published
09 Oct 2012

Chem. Commun., 2012,48, 11410-11412

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Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel

N. An, H. S. White and C. J. Burrows, Chem. Commun., 2012, 48, 11410 DOI: 10.1039/C2CC36366F

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