Issue 89, 2012
From the journal:

Chemical Communications

Effects of fullerene derivatives on bioluminescence and application for protease detection†

Junping Yu,a   Mirong Guan,bc   Fengyun Li,ac   Zhiping Zhang,a   Chunru Wang,b   Chunying Shu,*b   Hongping Wei*a  and  Xian-En Zhang*a  

* Corresponding authors

a State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, P. R. China
E-mail: hpwei@wh.iov.cn, x.zhang@wh.iov.cn
Fax: +86-27-87199492
Tel: +86-27-87199115

b Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructures and Nanotechnology, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China
E-mail: shucy@iccas.ac.cn
Fax: +86-27-87199492
Tel: +86-27-87199115

c Gradual School, Chinese Academy of Sciences, Beijing, 10049, P. R. China

Abstract

The effects of two C60 derivatives: C60[C(COOH)2]3 and C60(NH2)x(OH)y, have been investigated on the bioluminescence of humanized Gaussia luciferase (hGluc) for the first time. Utilizing the dual properties of carboxyl C60 with luminescence quenching and free radicals scavenging, a novel BRET system was constructed for protease detection with high sensitivity.

Graphical abstract: Effects of fullerene derivatives on bioluminescence and application for protease detection

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC36099C
Article type
Communication
Submitted
22 Jul 2012
Accepted
19 Sep 2012
First published
21 Sep 2012

Chem. Commun., 2012,48, 11011-11013

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Effects of fullerene derivatives on bioluminescence and application for protease detection

J. Yu, M. Guan, F. Li, Z. Zhang, C. Wang, C. Shu, H. Wei and X. Zhang, Chem. Commun., 2012, 48, 11011 DOI: 10.1039/C2CC36099C

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