Issue 68, 2012
From the journal:

Chemical Communications

Dearomatizing conversion of pyrazines to 1,4-dihydropyrazine derivatives via transition-metal-free diboration, silaboration, and hydroboration†

Kazuyuki Oshima,a   Toshimichi Ohmura*a  and  Michinori Suginome*a  

* Corresponding authors

a Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: ohmura@sbchem.kyoto-u.ac.jp, suginome@sbchem.kyoto-u.ac.jp
Fax: +81-75-383-2722
Tel: +81-75-383-2723

Abstract

Pyrazines and substituted pyrazines undergo addition of boron reagents having B–B, Si–B, and H–B bonds under transition-metal-free conditions, leading to high-yield synthesis of N-borylated 1,4-dihydropyrazines and 1,2,3,4-tetrahydropyrazine.

Graphical abstract: Dearomatizing conversion of pyrazines to 1,4-dihydropyrazine derivatives via transition-metal-free diboration, silaboration, and hydroboration

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Article information

DOI
https://doi.org/10.1039/C2CC34086K
Article type
Communication
Submitted
07 Jun 2012
Accepted
04 Jul 2012
First published
05 Jul 2012

Chem. Commun., 2012,48, 8571-8573

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Dearomatizing conversion of pyrazines to 1,4-dihydropyrazine derivatives via transition-metal-free diboration, silaboration, and hydroboration

K. Oshima, T. Ohmura and M. Suginome, Chem. Commun., 2012, 48, 8571 DOI: 10.1039/C2CC34086K

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