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Abstract | Cited by

Core histones play a critical role in the regulation of chromatin-templated biological process. Here we have developed a novel approach to enrich histone proteins based on the recognition of a specific aptamer. The method shows good selectivity toward histone proteins and is able to extract histones directly from complex whole cell lysates.

Graphical abstract: Preparation and characterization of DNA aptamer based spin column for enrichment and separation of histones

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