Issue 5, 2012
From the journal:

Chemical Communications

Direct amide formation from unactivated carboxylic acids and amines†

C. Liana Allen,a   A. Rosie Chhatwala  and  Jonathan M. J. Williams*a  

* Corresponding authors

a Department of Chemistry, University of Bath, Claverton Down, Bath, U.K
E-mail: j.m.j.williams@bath.ac.uk
Fax: +44 1225 386231
Tel: +44 1225 383942

Abstract

The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 °C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.

Graphical abstract: Direct amide formation from unactivated carboxylic acids and amines

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Article information

DOI
https://doi.org/10.1039/C1CC15210F
Article type
Communication
Submitted
22 Aug 2011
Accepted
08 Nov 2011
First published
28 Nov 2011

Chem. Commun., 2012,48, 666-668

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Direct amide formation from unactivated carboxylic acids and amines

C. L. Allen, A. R. Chhatwal and J. M. J. Williams, Chem. Commun., 2012, 48, 666 DOI: 10.1039/C1CC15210F

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