Issue 10, 2012
From the journal:

Chemical Communications

Modular synthesis of supramolecular ureidopyrimidinone–peptide conjugates using an oxime ligation strategy†‡

Roxanne E. Kieltyka,a   Maartje M. C. Bastings,a   Geert C. van Almen,a   Pol Besenius,a   Erwin W. L. Kempsa  and  Patricia Y. W. Dankers*a  

* Corresponding authors

a Institute for Complex Molecular Systems, and Laboratory of Chemical Biology, Eindhoven University of Technology (TU/e), PO Box 513, Eindhoven, The Netherlands
E-mail: p.y.w.dankers@tue.nl
Fax: +31 40 247 8367
Tel: +31 40 247 5620

Abstract

A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures.

Graphical abstract: Modular synthesis of supramolecular ureidopyrimidinone–peptide conjugates using an oxime ligation strategy

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Article information

DOI
https://doi.org/10.1039/C1CC14728E
Article type
Communication
Submitted
31 Jul 2011
Accepted
07 Oct 2011
First published
18 Oct 2011

Chem. Commun., 2012,48, 1452-1454

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Modular synthesis of supramolecular ureidopyrimidinone–peptide conjugates using an oxime ligation strategy

R. E. Kieltyka, M. M. C. Bastings, G. C. van Almen, P. Besenius, E. W. L. Kemps and P. Y. W. Dankers, Chem. Commun., 2012, 48, 1452 DOI: 10.1039/C1CC14728E

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