Issue 6, 2012

NMR reaction monitoring during the development of an active pharmaceutical ingredient

Abstract

We show the use of NMR spectroscopy to develop detailed understanding of a reaction mechanism during development of a manufacturing process for an active pharmaceutical ingredient (API). This includes structural elucidation of reaction starting materials, intermediates and products. The method is able to generate an immediate mass balance through quantitative profiling of all materials involved in the reaction. A straightforward reaction monitoring methodology was employed using existing laboratory based equipment.

Graphical abstract: NMR reaction monitoring during the development of an active pharmaceutical ingredient

Article information

Article type
Paper
Submitted
27 Jun 2011
Accepted
08 Sep 2011
First published
05 Oct 2011

Anal. Methods, 2012,4, 1498-1506

NMR reaction monitoring during the development of an active pharmaceutical ingredient

I. M. Clegg, C. M. Gordon, D. S. Smith, R. Alzaga and A. Codina, Anal. Methods, 2012, 4, 1498 DOI: 10.1039/C1AY05384A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements