Issue 16, 2011
From the journal:

Soft Matter

Protease-promoted drug delivery using peptide-functionalized gold nanoparticles†

Jianhao Wang,a   Yanan Yue,a   Gaojian Chena  and  Jiang Xia*a  

* Corresponding authors

a Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China
E-mail: jiangxia@cuhk.edu.hk

Abstract

Gold nanoparticles functionalized with amphiphilic peptides can encapsulate Bodipy and release it by diffusion. Proteolytic cleavage of the peptide monolayer triggers the rapid release of the encapsulated Bodipy from nanoparticles to mammalian cells, representing a prototypical model of protease-promoted drug delivery using gold nanoparticles.

Graphical abstract: Protease-promoted drug delivery using peptide-functionalized gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C1SM05242J
Article type
Paper
Submitted
14 Feb 2011
Accepted
11 May 2011
First published
24 Jun 2011

Soft Matter, 2011,7, 7217-7222

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Protease-promoted drug delivery using peptide-functionalized gold nanoparticles

J. Wang, Y. Yue, G. Chen and J. Xia, Soft Matter, 2011, 7, 7217 DOI: 10.1039/C1SM05242J

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