Issue 21, 2011
From the journal:

Organic & Biomolecular Chemistry

Perfluoroalkylation in flow microreactors: generation of perfluoroalkyllithiums in the presence and absence of electrophiles†

Aiichiro Nagaki,a   Shinya Tokuoka,a   Shigeyuki Yamada,a   Yutaka Tomida,a   Kojun Oshiro,b   Hideki Amiib  and  Jun-ichi Yoshida*a  

* Corresponding authors

a Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, Japan
E-mail: yoshida@sbchem.kyoto-u.ac.jp
Fax: +81-75-383-2725
Tel: +81-75-383-2726

b Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University,

Abstract

Perfluoroalkyllithiums were effectively generated from perfluoroalkyl halides in the presence and absence of electrophiles using flow microreactor systems. The in situ trapping with electrophile is conducted at much higher temperatures than those required for batch macro reactors. The subsequent trapping method is quite effective for highly reactive electrophiles that are not compatible with the lithiation process.

Graphical abstract: Perfluoroalkylation in flow microreactors: generation of perfluoroalkyllithiums in the presence and absence of electrophiles

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Article information

DOI
https://doi.org/10.1039/C1OB06350B
Article type
Paper
Submitted
16 Jun 2011
Accepted
16 Aug 2011
First published
22 Sep 2011

Org. Biomol. Chem., 2011,9, 7559-7563

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Perfluoroalkylation in flow microreactors: generation of perfluoroalkyllithiums in the presence and absence of electrophiles

A. Nagaki, S. Tokuoka, S. Yamada, Y. Tomida, K. Oshiro, H. Amii and J. Yoshida, Org. Biomol. Chem., 2011, 9, 7559 DOI: 10.1039/C1OB06350B

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