Issue 19, 2011
From the journal:

Organic & Biomolecular Chemistry

Bifunctional phosphine-catalyzed cross-Rauhut–Currier/Michael/aldol condensation triple domino reaction: synthesis of functionalized cyclohexenes†

Peizhong Xie,a   You Huang,*a   Wenqing Lai,a   Xiangtai Menga  and  Ruyu Chen*a  

* Corresponding authors

a State Key Laboratory and Institute of Elemento-organic Chemistry Nankai University, Tianjin 300071, People's Republic of China
E-mail: hyou@nankai.edu.cn
Fax: (+86) 22-23503627
Tel: (+86) 22-23508857

Abstract

A novel bifunctional phosphine-catalyzed reaction was developed. Cross-Rauhut–Currier, Michael and aldol reactions were successfully combined into a domino process. This method offers a powerful approach to the construction of highly substituted cyclohexene skeletons.

Graphical abstract: Bifunctional phosphine-catalyzed cross-Rauhut–Currier/Michael/aldol condensation triple domino reaction: synthesis of functionalized cyclohexenes

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Article information

DOI
https://doi.org/10.1039/C1OB05693J
Article type
Paper
Submitted
02 May 2011
Accepted
23 Jun 2011
First published
23 Jun 2011

Org. Biomol. Chem., 2011,9, 6707-6714

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Bifunctional phosphine-catalyzed cross-Rauhut–Currier/Michael/aldol condensation triple domino reaction: synthesis of functionalized cyclohexenes

P. Xie, Y. Huang, W. Lai, X. Meng and R. Chen, Org. Biomol. Chem., 2011, 9, 6707 DOI: 10.1039/C1OB05693J

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