Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor†
Abstract
The considerable interest in substituted isoquinolin-1-ones related to
* Corresponding authors
a
Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath, UK
E-mail:
m.d.threadgill@bath.ac.uk
Fax: +44 1225 386114
Tel: +44 1225 386840
b Crystallography Unit, Department of Chemistry, University of Bath, Claverton Down, Bath, UK
c KuDOS Pharmaceuticals Ltd., 410 Cambridge Science Park, Milton Road, Cambridge, UK
The considerable interest in substituted isoquinolin-1-ones related to
P. T. Sunderland, A. Dhami, M. F. Mahon, L. A. Jones, S. R. Tully, M. D. Lloyd, A. S. Thompson, H. Javaid, N. M. B. Martin and M. D. Threadgill, Org. Biomol. Chem., 2011, 9, 881 DOI: 10.1039/C0OB00665C
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