EuII-containing cryptates as contrast agents for ultra-high field strength magnetic resonance imaging

Joel Garcia; Jaladhar Neelavalli; E. Mark Haacke; Matthew J. Allen

doi:10.1039/C1CC15219J

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Eu^II-containing cryptates as contrast agents for ultra-high field strength magnetic resonance imaging†

Joel Garcia,^a Jaladhar Neelavalli,^b E. Mark Haacke^b and Matthew J. Allen*^a

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* Corresponding authors

^a Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, USA
E-mail: mallen@chem.wayne.edu
Fax: 1 313 577 8822
Tel: 1 313 577 2070

^b Department of Radiology, Wayne State University, Detroit, USA

Abstract

The relaxivity (contrast-enhancing ability) of Eu^II-containing cryptates was found to be better than a clinically approved Gd^III-based agent at 7 T. These cryptates are among a few examples of paramagnetic substances that show an increase in longitudinal relaxivity, r₁, at ultra-high field strength relative to lower field strengths.

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Article information

DOI: https://doi.org/10.1039/C1CC15219J
Article type: Communication
Submitted: 22 Aug 2011
Accepted: 20 Oct 2011
First published: 02 Nov 2011

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Chem. Commun., 2011,47, 12858-12860

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Eu^II-containing cryptates as contrast agents for ultra-high field strength magnetic resonance imaging

J. Garcia, J. Neelavalli, E. M. Haacke and M. J. Allen, Chem. Commun., 2011, 47, 12858 DOI: 10.1039/C1CC15219J

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