Issue 37, 2011

Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

Abstract

Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.

Graphical abstract: Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
17 Jun 2011
Accepted
21 Jul 2011
First published
18 Aug 2011

Chem. Commun., 2011,47, 10260-10262

Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

C. E. Martin, M. W. Weishaupt and P. H. Seeberger, Chem. Commun., 2011, 47, 10260 DOI: 10.1039/C1CC13614C

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