Issue 19, 2011
From the journal:

Chemical Communications

A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand–receptor binding†

Yong Yang,a   Yongchun Xu,a   Tie Xia,a   Fangjin Chen,b   Chunling Zhang,c   Wei Liang,c   Luhua Laib  and  Xiaohong Fang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Key Laboratory of Molecular Nanostructures and Nanotechnology, Chinese Academy of Sciences, Beijing 100190, P.R. China
E-mail: xfang@iccas.ac.cn
Fax: +86-10-62650024
Tel: +86-10-62650024

b Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China

c Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 10010, P.R. China

Abstract

With single-molecule fluorescence imaging and single-molecule force measurement, we have found that the natural compound Naringenin exerts an inhibition effect on TGF-β ligand–receptor interaction, the initial step of TGF-βsignaling.

Graphical abstract: A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand–receptor binding

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC10778J
Article type
Communication
Submitted
10 Feb 2011
Accepted
16 Mar 2011
First published
08 Apr 2011

Chem. Commun., 2011,47, 5440-5442

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A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand–receptor binding

Y. Yang, Y. Xu, T. Xia, F. Chen, C. Zhang, W. Liang, L. Lai and X. Fang, Chem. Commun., 2011, 47, 5440 DOI: 10.1039/C1CC10778J

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