Issue 6, 2010
From the journal:

Organic & Biomolecular Chemistry

A concise synthesis of enantiopure circumdatins E, H and J†

Paul E. Zhichkin,*a   Xiaomin Jin,a   Honglu Zhang,a   Lisa H. Peterson,a   Catherine Ramirez,b   Tara M. Snyderb  and  Hilde S. Burtonb  

* Corresponding authors

a Medicinal Chemistry Department, AMRI, 26 Corporate Circle P.O. Box 15098, Albany, New York, USA
E-mail: Paul.Zhichkin@amriglobal.com
Fax: +1 518 512-2079
Tel: +1 518 512-2000

b Pharmaceutical Development Department, AMRI, 26 Corporate Circle P.O. Box 15098, Albany, New York, USA

Abstract

A concise total synthesis of enantiopure circumdatins E, H and J has been developed using a reductive cyclization of chiral N-prolinoyl-2-nitrobenzamides to construct the core quinazolinone ring.

Graphical abstract: A concise synthesis of enantiopure circumdatins E, H and J

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Article information

DOI
https://doi.org/10.1039/B925494C
Article type
Communication
Submitted
03 Dec 2009
Accepted
18 Jan 2010
First published
27 Jan 2010

Org. Biomol. Chem., 2010,8, 1287-1289

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A concise synthesis of enantiopure circumdatins E, H and J

P. E. Zhichkin, X. Jin, H. Zhang, L. H. Peterson, C. Ramirez, T. M. Snyder and H. S. Burton, Org. Biomol. Chem., 2010, 8, 1287 DOI: 10.1039/B925494C

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