A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79–99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.
G. Zhang, D. Zheng, J. Nie, T. Wang and J. Ma, Org. Biomol. Chem., 2010, 8, 1399 DOI: 10.1039/B924272D
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