Issue 6, 2010
From the journal:

Organic & Biomolecular Chemistry

Exploring neoglycoproteinassembly through native chemical ligation using neoglycopeptide thioesters prepared via N→S acyl transfer†‡

Jonathan P. Richardson,a   Chung-Hei Chan,a   Javier Blanc,a   Mona Saadia  and  Derek Macmillan*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: d.macmillan@ucl.ac.uk

Abstract

Sugars and simplified oligosaccharide “mimics” can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.

Graphical abstract: Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N→S acyl transfer

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Article information

DOI
https://doi.org/10.1039/B920535G
Article type
Paper
Submitted
01 Oct 2009
Accepted
17 Dec 2009
First published
22 Jan 2010

Org. Biomol. Chem., 2010,8, 1351-1360

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Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N→S acyl transfer

J. P. Richardson, C. Chan, J. Blanc, M. Saadi and D. Macmillan, Org. Biomol. Chem., 2010, 8, 1351 DOI: 10.1039/B920535G

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