Issue 2, 2010
From the journal:

Green Chemistry

Screening of new solvents for artemisininextraction process using ab initio methodology†

Alexei A. Lapkin,*a   Martina Peters,b   Lasse Greiner,b   Smain Chemat,c   Kai Leonhard,de   Marcel A. Liauwb  and  Walter Leitnerb  

* Corresponding authors

a School of Engineering, University of Warwick, Coventry, UK
E-mail: a.lapkin@warwick.ac.uk
Fax: +44(0)2476 418922
Tel: +44 (0)2476 151101

b Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Aachen, Germany

c Department of Chemical Engineering, University of Bath, UK

d Chair of Technical Thermodynamics, RWTH Aachen University, Germany

e Engineering Thermodynamics, Delft University of Technology, Delft, The Netherlands

Abstract

The solubility of artemisinin in a range of conventional and novel solvents was evaluated using the COSMO-RS approach, and verified experimentally as well as against literature data. The computational method was improved by calibrating against a limited set of experimental data, enhancing the accuracy of the calculations. The optimised method was shown to be in reasonable agreement with experimental data; however, lack of reliable experimental data is identified as an issue. Several novel solvents perceived as green alternatives to conventional solvents were targeted and shown to offer good solubility of artemisinin. Extraction from Artemisia annua by carbonate solvents was experimentally verified.

Graphical abstract: Screening of new solvents for artemisinin extraction process using ab initio methodology

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Article information

DOI
https://doi.org/10.1039/B922001A
Article type
Paper
Submitted
23 Oct 2009
Accepted
28 Oct 2009
First published
30 Nov 2009

Green Chem., 2010,12, 241-251

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Screening of new solvents for artemisinin extraction process using ab initio methodology

A. A. Lapkin, M. Peters, L. Greiner, S. Chemat, K. Leonhard, M. A. Liauw and W. Leitner, Green Chem., 2010, 12, 241 DOI: 10.1039/B922001A

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