Issue 22, 2010
From the journal:

Chemical Communications

Ceramide-mediated transport of chloride and bicarbonate across phospholipidmembranes†

William A. Harrell, Jr.,a   Marie Liesel Bergmeyer,a   Peter Y. Zavalija  and  Jeffery T. Davis*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Maryland, College Park, USA
E-mail: jdavis@umd.edu
Fax: 001-301-314-9121
Tel: 001-301-441-3140

Abstract

The sphingolipid, ceramide 1, facilitates transport of Cl− and HCO3− anions across lipid bilayers under conditions where large transmembrane pores are not formed. Ceramide's 1,3-diol unit is essential for both binding and transporting these anions.

Graphical abstract: Ceramide-mediated transport of chloride and bicarbonate across phospholipid membranes

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Article information

DOI
https://doi.org/10.1039/C0CC00493F
Article type
Communication
Submitted
19 Mar 2010
Accepted
13 Apr 2010
First published
29 Apr 2010

Chem. Commun., 2010,46, 3950-3952

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Ceramide-mediated transport of chloride and bicarbonate across phospholipid membranes

W. A. Harrell, Jr., M. L. Bergmeyer, P. Y. Zavalij and J. T. Davis, Chem. Commun., 2010, 46, 3950 DOI: 10.1039/C0CC00493F

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